Auditory cortex damage9/12/2023 ![]() Sustained potentiation of excitatory ACtx projection neurons that innervate multiple limbic and subcortical auditory centers may underlie hyperexcitability and aberrant functional coupling of distributed brain networks in tinnitus and hyperacusis. Corticocollicular response gain rebounded above baseline levels by the following day and remained elevated for several weeks despite a persistent reduction in auditory nerve input. Sound level growth functions at the level of the auditory nerve and corticocollicular axon terminals are both strongly depressed hours after noise-induced damage of cochlear afferent synapses. We track daily changes in sound processing using chronic widefield calcium imaging of L5 axon terminals on the dorsal cap of the IC in awake, adult mice. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. ![]() Optical steroid injections are sometimes used in those situations, but their success is not a guarantee.Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. In retrospect we now know it was optical neuritis rather than vitreous gel separation. Later I underwent optical nerve testing, which indicated nerve damage and finally pinpointed the cause of my temporary vision loss.Īlso, there was nothing to treat. It also normally happens without severe symptoms.īecause my symptoms were so severe, my retinal specialist conducted an optical angiogram and saw me weekly, then every other week and finally monthly. That is actually a normal process, but it typically happens in our 60s or 70s. From an Optic Coherence Tomography my retinal specialist could see the vitreous gel separating from my eye. My ophthalmologist could see the eye floaters with a simple exam. Oh and my pupil in the blind eye did not dilate. They asked me to read letters and I asked them what letters, I could not see them. ![]() I completely failed color and vision exams. The “fireworks” were not occasional - which can be normal - but nonstop. I just want a better idea of where on my head I can whack or cut so as to damage it.Ĭlick to expand.There was no need to convince them, it was obvious I was unable to see. I have looked at some diagrams showing it in the brain and both are located on the edge of the brain, so it has no other tissue too hide behind. So I will have to use the old fashion cave man method of whacking the side of my head where the auditory cortex is closest to the skull in hopes of causing irreversible damage. I don't have the money to go to Asia and bombard it (and any tissue the brain might use to compensate or replace the damage neural clusters, because the goal to to recreate the gap in hearing AND deprive the brain of an ability to compensate) with radiation. Since tinnitus is the result of hyperactivity in the auditory cortex, I have long sought treatment that greatly antagonizes neurons (such as cleaving synapses off or tearing the mylein sheath apart) to hurt the previous neural connection that brain so desperately wants so that glowing auditory cortex begins to go dark and never light up again.
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